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Description: Acid-PEG4-Val-Cit-PAB-MMAE is a cleavable ADC linker featuring a carboxylic acid, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide ligated to an MMAE payload. Carboxylic acids are reactive towards amines or alcohols while the Val-Cit-PAB motif is an enzyme-cleavable linker. This linker efficiently releases the toxin, MMAE, to target cells to cause cellular apoptosis.
Format: Solid
Purity: 0,98
Storage Stability: At least 6 months at -20°C.
Warnings: Avoid freeze/thaw cycles. See SDS for additional warnings and handling.
Biosafety Level: Not applicable (BSL-1)