Adagrasib, CAS 2326521-71-3

Description: Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib exhibits inhibitory activity against KRAS G12C mutant tumors.

CAS Number: 2326521-71-3

Formula: C32H35ClFN7O2

Molecular Weight: 604,12

References: Hallin J, et al. The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients. Cancer Discov. 2020 Jan;10(1):54-71.

• SKU: TGMT8369-1mL
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T8369-1mL
• Package Unit: 1 mL
• Quantity Unit: STK