Product Description: Amyloid precursor C-terminal peptide is cleaved from the C-terminus of Amyloid Precursor Protein (APP). Amyloid precursor C-terminal peptide accumulation causes mitochondrial morphology alteration and basal mitophagy failure, which indicates that amyloid precursor protein C-terminal peptide may correspond to an etiological trigger of Alzheimer’s disease (AD) pathology[1].
Applications: Neuroscience-Neuromodulation
Formula: C86H118N20O27S
References: [1]Vaillant-Beuchot L, et al., Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains. Acta Neuropathol. 2021 Jan;141(1):39-65.
CAS Number: 201293-38-1
Molecular Weight: 1896.04
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Others
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