Product Description: Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell[1].
Applications: COVID-19-immunoregulation
Formula: C21H12N2O6S2
References: [1]Ahmed GE, et al., Synthesis, biofilm formation inhibitory, and inflammation inhibitory activities of new coumarin derivatives. Sci Rep. 2024 Apr 20;14(1):9106.
Molecular Weight: 452.46
Research Area: Infection; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: Bacterial;Fungal
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