Anti-osteoporosis agent-8

Product Description: Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model[1].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C18H19F3N2O2Se

References: [1]Wu Y, et al., Design, Synthesis, and Biological Evaluation of β-Trifluoroethoxydimethyl Selenides as Potent Antiosteoporosis Agents. J Med Chem. 2024 May 9;67(9):7585-7602.

Molecular Weight: 431.31

Research Area: Endocrinology

Solubility: 10 mM in DMSO

Target: NF-κB;p38 MAPK;RANKL/RANK

• SKU: MEXHY-158311-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158311-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK