Product Description: Anticancer agent 205 (compound 9) is a potent anticancer agent. Anticancer agent 205 binds to G4-mtDNA target and inhibits the replication, transcription, and translation of mtDNA (mitochondrial genome). Anticancer agent 205 causes mitochondrial dysfunction, increases ROS production, induces DNA damage and cellular senescence. Anticancer agent 205 induces apoptosis and cell cycle arrests at G0/G1 phase. Anticancer agent 205 has the potential for the research of colorectal cancer[1].
Formula: C52H60I2N4
References: [1]Zheng BX, et al. Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy. J Med Chem. 2024 Apr 25;67(8):6292-6312.
Molecular Weight: 994.87
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Apoptosis;Reactive Oxygen Species
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