Product Description: Antifolate C2 is an anti-folate compound that has inhibitory effects on the proliferation of non-squamous non-small cell lung cancer (NS-NSCLC). Antifolate C2 achieves tumor selectivity by targeting proton-coupled folate transporter (PCFT), which is more selective to PCFT than the commonly used anti-folate drug Pemetrexed (HY-10820). Antifolate C2 blocks the biosynthesis of deoxypurine nucleotides by inhibiting glycinamide ribonucleotide formyltransferase (GARFTase), ultimately inhibiting the proliferation of tumor cells. Antifolate C2 can be used in studies of NS-NSCLC, especially in patients who do not respond well to Pemetrexed[1].
Formula: C19H21N5O6S
References: [1]Wilson M R, et al. Targeting nonsquamous nonsmall cell lung cancer via the proton-coupled folate transporter with 6-substituted pyrrolo [2, 3-d] pyrimidine thienoyl antifolates[J]. Molecular pharmacology, 2016, 89(4): 425-434.
CAS Number: 1286279-90-0
Molecular Weight: 447.46
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Antifolate;Apoptosis