Antitumor agent-153

Product Description: Antitumor agent-153 (compound 11b) is an optimized H2A histone ubiquitination inhibitor based on PRT4165 (HY-19817). Antitumor agent-153 inhibits the viability of human osteosarcoma U2OS cells and reduces histone H2A monoubiquitination, exhibiting anticancer activity.[12][1].

Formula: C16H8N2O6

References: [1]Ni S, et al. Identification of a novel histone H2A mono-ubiquitination-inhibiting cell-active small molecule. Bioorg Med Chem Lett. 2024 Jun 1;105:129759.

Molecular Weight: 324.24

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: E1/E2/E3 Enzyme

• SKU: MEXHY-163518-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163518-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK