ARN5187 (trihydrochloride), CAS 1700693-96-4

Product Description: ARN5187 trihydrochloride is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride shows lysosomotropic potency and cytotoxicity. ARN5187 trihydrochloride induces apoptosis[1][2].

Applications: COVID-19-immunoregulation

Formula: C24H35Cl3FN3O

References: [1]De Mei C, et al. Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells. Oncogene. 2015 May 14;34(20):2597-608. /[2]Torrente E, et al. Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy. J Med Chem. 2015 Aug 13;58(15):5900-15.

CAS Number: 1700693-96-4

Molecular Weight: 506.91

Compound Purity: 99.54

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;Autophagy;REV-ERB

• SKU: MEXHY-103691A-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-103691A-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK