AurkA allosteric-IN-1

Product Description: AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA[1].

Applications: Cancer-Kinase/protease

Formula: C20H16N2O3

References: [1]Lee H, et al. Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A. Bioorg Med Chem. 2024 Mar 15;102:117658.

Molecular Weight: 332.35

Research Area: cancer

Solubility: 10 mM in DMSO

Target: Aurora Kinase

• SKU: MEXHY-158038-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158038-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK