Beclin1-ATG14L interaction inhibitor 1, CAS 1243063-73-1

Product Description: Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport[1].

Formula: C23H24N4O5S

References: [1]Pavlinov I, et al. Beclin 1-ATG14L Protein-Protein Interaction Inhibitor Selectively Inhibits Autophagy through Disruption of VPS34 Complex I. J Am Chem Soc. 2020 May 6;142(18):8174-8182.

CAS Number: 1243063-73-1

Molecular Weight: 468.53

Compound Purity: 99.88

Research Area: Others

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Autophagy

• SKU: MEXHY-156237-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-156237-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK