BI-2865, CAS 2937327-93-8

Description: BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.

CAS Number: 2937327-93-8

Formula: C23H27N7O2S

Molecular Weight: 465,57

References: Kim D, et al. Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature. 2023;619(7968):160-166.

• SKU: TGMT72062-1mL
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T72062-1mL
• Package Unit: 1 mL
• Quantity Unit: STK