Product Description: BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7[1].
Formula: C24H27N5O4
References: [1]Pfaffenbach M, et al., Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J Med Chem. 2024 May 23;67(10):8383-8395.
CAS Number: 2792153-06-9
Molecular Weight: 449.50
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: IRAK