Product Description: Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 (Compound 24, Cys modified with M6Pn) is a mannose-6-phosphate (M6Pn)-peptide conjugate capable of binding to targeted ligands of various proteins and successfully internalizing and degrading them through M6PR. Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 can be utilized in the research of lysosomal targeting chimeras (LYTACs) based on M6Pn[1].
Applications: Cancer-programmed cell death
Formula: C124H230N20O63P6S7
References: [1]Stevens CM, et al. Development of Oligomeric Mannose-6-phosphonate Conjugates for Targeted Protein Degradation. ACS Med Chem Lett. 2023;14(6):719-726. Published 2023 Mar 3.