Product Description: Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].
Applications: Cancer-programmed cell death
Formula: C43H36Cl2N8O5
References: [1]J M Woynarowski, et al. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem. 2001 Nov 2;276(44):40555-66. /[2]J M Woynarowski, et al. Effects of bizelesin (U-77,779), a bifunctional alkylating minor groove binder, on replication of genomic and simian virus 40 DNA in BSC-1 cells. Biochim Biophys Acta. 1997 Jul 17;1353(1):50-60.
CAS Number: 129655-21-6
Molecular Weight: 815.70
Compound Purity: 95.07
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: DNA Alkylator/Crosslinker
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