Product Description: BMS-394136 (compound 1) is a potent inhibitor of Kv 1.5, with an IC50 of 0.05 μM. BMS-394136 is a selective IKur inhibitor. BMS-394136 dose-dependently prolongs atrial effective refractory period (AERP) and action potential duration (APD) without effecting ventricular effective refractory period (VERP). BMS-394136 can be used for acute atrial ischemia research[1].
Applications: Neuroscience-Neuromodulation
Formula: C24H21Cl2FN4O
References: [1]Gunaga P, et al. Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide. J Med Chem. 2017 May 11;60(9):3795-3803./[2]Dezhi Xing, et al. Abstract 12964: Acute Atrial Ischemia Increases the Activity of BMS-394136, a Selective IKur Inhibitor, on Atrial Refractoriness and APD. Originally published 23 Mar 2018. Circulation. 2010;122:A12964.
CAS Number: 343246-73-1
Molecular Weight: 471.35
Research Area: Cardiovascular Disease
Solubility: 10 mM in DMSO
Target: Potassium Channel
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