BRD0705, CAS 2056261-41-5

Product Description: BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML) research[1].

Applications: Cancer-Kinase/protease

Formula: C20H23N3O

References: [1]Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.

CAS Number: 2056261-41-5

Molecular Weight: 321.42

Compound Purity: 99.80

Research Area: Cancer

Solubility: DMSO : 300 mg/mL (ultrasonic)

Target: GSK-3

• SKU: MEXHY-116830-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-116830-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK