BRD4 degrader-2

Product Description: BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells[1][2].

Formula: C34H33ClN6O4S

References: [1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Central Science. DOI: 10.1021/acscentsci.4c00286/[2]Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9(5):915-926.

Molecular Weight: 657.18

Research Area: Cancer

Target: Epigenetic Reader Domain;Molecular Glues

• SKU: MEXHY-163639-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-163639-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK