BRD4/NAMPT-IN-1

Product Description: BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects[1].

Applications: Cancer-programmed cell death

Formula: C30H30ClN7O2S

References: [1]Yin C, et al. Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma. Eur J Med Chem. 2024 May 5;271:116444.

Molecular Weight: 588.12

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Epigenetic Reader Domain;NAMPT

• SKU: MEXHY-161515-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161515-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK