BTL-MK, CAS 2758569-43-4

Product Description: BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability[1].

Formula: C24H24O6

References: [1]Xie CL, et al., Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB. J Med Chem. 2024 May 9;67(9):7504-7515.

CAS Number: 2758569-43-4

Molecular Weight: 408.44

Research Area: Others

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-158316-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158316-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK