Product Description: BVT 2733 is a potent, selective, and orally active non-steroidal 11β-hydroxydehydrogenase 1 (11β-HSD1) inhibitor. BVT 2733 is potently against the mouse enzyme (IC50=96 nM) over the human enzyme (IC50=3341 nM). BVT 2733 has the potential for the study of arthritis and obesity related disease[1].
Applications: COVID-19-immunoregulation
Formula: C17H21ClN4O3S2
References: [1]Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17(3):489-94./[2]Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7(7):e40056./[3]11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development
CAS Number: 376640-41-4
Molecular Weight: 428.96
Compound Purity: 99.72
Research Area: Inflammation/Immunology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: 11β-HSD
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