Product Description: BWA-522 intermediate-1 is an intermediate in the synthesis of PROTAC BWA-522 (HY-149433) and serves as a ligand molecule for cereblon E3 ubiquitin ligase. BWA-522 is an orally active small molecule protein-targeting chimera (PROTAC) that has significant degradation effects on AR-FL and AR-V7[1].
Applications: Cancer-programmed cell death
Formula: C19H19N3O5
References: [1]Arvinas Operations, et al. Indazole based compounds and associated methods of use. World Intellectual Property Organization, WO2021194879 A1 2021-09-30.