Product Description: C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation[1][2].
Applications: Metabolism-sugar/lipid metabolism
Formula: C30H36FN3O4S
References: [1]Clark RD, et al. 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity. Bioorg Med Chem Lett. 2008;18(4):1312-1317./[2]van den Heuvel JK, et al. Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation. Br J Pharmacol. 2016;173(11):1793-1804.
CAS Number: 864972-30-5
Molecular Weight: 553.69
Compound Purity: 99.97
Research Area: Metabolic Disease; Inflammation/Immunology
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Glucocorticoid Receptor
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