CAF-382

Product Description: CAF-382 (compound B1) is an analog of SNS-032 and a CDKL5 and pan-CDK inhibitor with a weak GSK3α/β affinity (>1.8 μM) and inhibitory activity. CAF-382 inhibits CDKL5 and blocks the phosphorylation of the CDKL5 E2 domain[1].

Formula: C16H22N4O2S2

References: [1]Castano A, et al. Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology. Elife. 2023 Jul 25;12:e88206.

Molecular Weight: 366.50

Compound Purity: 98.0

Research Area: cancer

Solubility: 10 mM in DMSO

Target: CDK

• SKU: MEXHY-155805-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-155805-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK