cGAS-IN-3

Product Description: cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].br/[16][1].

Formula: C21H20Cl2F2N4O2

References: [1]Chen M, et al. Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury. J Med Chem. 2024 Apr 25;67(8):6268-6291.

Molecular Weight: 469.31

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Cyclic GMP-AMP Synthase

• SKU: MEXHY-162459-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162459-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK