Product Description: Chembridge-5861528 (TCS 5861528) is a potent TRPA1 channel antagonist that antagonizes similarly allyl isothiocyanate- and 4-HNE-evoked TRPA1 responses, with IC50 values of 14.3 μM and 18.7 μM, respectively. Chembridge-5861528 shows antihypersensitivity activities[1].
Applications: Neuroscience-Neuromodulation
Formula: C19H23N5O3
References: [1]Wei H, et al. Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology. 2009 Jul;111(1):147-54./[2]Wei H, et al. Spinal TRPA1 ion channels contribute to cutaneous neurogenic inflammation in the rat. Neurosci Lett. 2010 Aug 2;479(3):253-6.
CAS Number: 332117-28-9
Molecular Weight: 369.42
Compound Purity: 99.76
Research Area: Metabolic Disease; Inflammation/Immunology; Neurological Disease
Solubility: DMSO : 120 mg/mL (ultrasonic)
Target: TRP Channel
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