cis-MZ 1 (hydrate)

Product Description: cis-MZ 1 hydrate is a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 or MZ 1 is a combination of the von Hippel-Lindau ligand (red part in the structural formula) and the BRD4 ligand (blue part in the structural formula). The Kd of MZ 1 for BRD4 BD1/2 was 382 nM and 120 nM, respectively[1].

Formula: C49H60ClN9O8S2.1/4H2O

References: [1]Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.

Molecular Weight: 1007.15

Compound Purity: 99.0

Research Area: cancer

Solubility: 10 mM in DMSO

Target: Epigenetic Reader Domain

• SKU: MEXHY-107425B-1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-107425B-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK