CL 5343, CAS 14949-00-9

Product Description: CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is an inhibitor of human carbonic anhydrase B (HCA-B). CL 5343 can serve as a CA9 ligand to achieve the targeted delivery of maytansinoid to the cell membrane of SKRC52 renal cancer cells[1][2].

Formula: C2H4N4O2S2

References: [1]Pérez-Herrero E, et al. The reversed intra-and extracellular pH in tumors as a unified strategy to chemotherapeutic delivery using targeted nanocarriers[J]. Acta Pharmaceutica Sinica B, 2021, 11(8): 2243-2264./[2]Pesando JM, et al. Proton magnetic resonance studies of carbonic anhydrase. III. Binding of sulfonamides. Biochemistry. 1975;14(4):689-693.

CAS Number: 14949-00-9

Molecular Weight: 180.21

Compound Purity: 98.0

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Carbonic Anhydrase

• SKU: MEXHY-W074975-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W074975-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK