Product Description: CS640 is a selective inhibitor of calmodulin-dependent kinases. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4 and MLK3 with IC50 values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69 and 2.75 μM, respectively. CS640 also shows inhibitory effects to CYP450 2C9 and CYP450 2C19 with IC50 values of 6 and 10 μM, respectively[1].
Applications: Cancer-Kinase/protease
Formula: C21H31N7O
References: [1]Fromont C, et al. Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model. J Med Chem. 2020 Jul 9;63(13):6784-6801.
CAS Number: 2388506-83-8
Molecular Weight: 397.52
Compound Purity: 99.43
Research Area: Cancer
Solubility: DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Biochemical Assay Reagents
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