CVN293, CAS 2815296-08-1

Product Description: CVN293 is a selective and brain permeable potassium ion (K+) channel KCNK13 inhibtor with IC50s of 41 nM and 28 nM for hKCNK13 and mKCNK13, respectively. CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia[1].

Applications: COVID-19-immunoregulation

Formula: C14H10FN7O

References: [1]Roland W. Bürli, et al.Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment. ACS Med. Chem. Lett. 2024.

CAS Number: 2815296-08-1

Molecular Weight: 311.27

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Potassium Channel

• SKU: MEXHY-158155-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158155-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK