Product Description: CW2158 (Compound 13) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].
Applications: Cancer-programmed cell death
Formula: C14H8F4N4O2
References: [1]Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25.
Molecular Weight: 340.23
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: CRM1