Formulation: A crystalline solid
Formal Name: S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl]propanethioic acid, 2-methyl ester
Purity: ≥98%
Formula Markup: C23H35NO2S
Formula Weight: 389,6
Shelf life (days): 1460
CAS Number: 211513-37-0
Notes: Cholesteryl ester transfer protein (CETP) is an exchange protein which transfers cholesteryl esters from HDL to VLDL, IDL, and LDL in exchange for triglycerides.{11793,15303} Dalcetrapib is an inhibitor of CETP that exhibits an IC50 value of 9 µM for plasma CETP in rabbits.{8320} Inhibition of CETP by dalcetrapib in rabbits given an atherogenic diet leads to elevation of HDL, decreased VLDL, and attenuation of the induced atherosclerosis.{8320} In human subjects, dalcetrapib also inhibits CETP activity and increases plasma HDL levels but it does not reduce the risk of recurrent cardiovascular events.{15303,21933}
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