Product Description: DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells[1]. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance[2].
Applications: COVID-19-immunoregulation
Formula: C9H8Cl2N2O
References: [1]Hamilton KL,et al. DCEBIO stimulates Cl- secretion in the mouse jejunum. Am J Physiol Cell Physiol. 2006 Jan;290(1):C152-64./[2]Singh S, et al. Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2001 Feb;296(2):600-11.
CAS Number: 60563-36-2
Molecular Weight: 231.08
Compound Purity: 99.89
Research Area: Inflammation/Immunology
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Potassium Channel