Dibutyryl-cGMP (sodium), CAS 51116-00-8

Product Description: Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [3H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K+ channels[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C18H23N5NaO9P

References: [1]Borán MS, et al. The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes. J Neurochem. 2007 Jul;102(1):216-30./[2]Sane DC, et al. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. Biochem Biophys Res Commun. 1989 Dec 15;165(2):708-14./[3]Soares AC, et al. Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw. Br J Pharmacol. 2001 Sep;134(1):127-31.

CAS Number: 51116-00-8

Molecular Weight: 507.37

Compound Purity: 99.55

Research Area: Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)

Target: Potassium Channel

• SKU: MEXHY-130354-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-130354-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK