Description: Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.
CAS Number: 97-77-8
Formula: C10H20N2S4
Molecular Weight: 296,54
References: Nasrollahzadeh A, et al. Anti-proliferative activity of disulfiram through regulation of the AKT-FOXO axis: A proteomic study of molecular targets. Biochim Biophys Acta Mol Cell Res. 2021 Sep;1868(10):119087.