DN-1289, CAS 3026597-15-6

Product Description: DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability[1].

Applications: Neuroscience-Neuromodulation

Formula: C18H19F4N7O2

References: [1]Craig RA 2nd, et al. Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis. J Med Chem. 2022 Dec 22;65(24):16290-16312.

CAS Number: 3026597-15-6

Molecular Weight: 441.38

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: JNK

• SKU: MEXHY-152142-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-152142-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK