DNA-PK-IN-13

Product Description: DNA-PK-IN-13 (Compound SK10) is a DNA-PK inhibitor that exhibits potent inhibitory activity (IC50= 0.11 nM). DNA-PK-IN-13 regulates tumor cell proliferation by decreasing the expression level of γH2A.X and enhancing the sensitivity of tumor cells to chemotherapeutic agents. DNA-PK-IN-13 is suitable for oncology studies[1].

Applications: COVID-19-anti-virus

Formula: C22H22N8O

References: [1]Cheng B, Y et al. Discovery of Novel Heterotricyclic Compounds as DNA-Dependent Protein Kinase (DNA-PK) Inhibitors with Enhanced Chemosensitivity, Oral Bioavailability, and the Ability to Potentiate Cancer Immunotherapy. J Med Chem. 2024 Apr 25;67(8):6253-6267

Molecular Weight: 414.46

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: DNA-PK

• SKU: MEXHY-158166-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158166-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK