DNMT3A-IN-3

Product Description: DNMT3A-IN-3 is an allosteric DNA methyltransferase 3A (DNMT3A) inhibitor. DNMT3A-IN-3 binds and disrupt protein-protein interactions (PPIs) at the DNMT3A tetramer interface[1].

Formula: C30H38N6O4

References: [1]Jonathan E SandovalA, et al. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022 Aug 11;65(15):10554-10566. /[2]Sunzeyu Huang, et al. A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A. Bioorg Med Chem Lett. 2021 May 15:40:127908.

Molecular Weight: 546.66

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: DNA Methyltransferase

• SKU: MEXHY-158165-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-158165-0
• Package Unit: Get quote
• Quantity Unit: STK