Product Description: DW18134 is an inhibitor for interleukin receptor-associated kinase 4 (IRAK 4) with an IC50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK, downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides (HY-D1056)-induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function [1].
Formula: C24H21N5O3
References: [1]Huang Y, et al., A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease. Molecules. 2024 Apr 16;29(8):1803.
CAS Number: 2626988-87-0
Molecular Weight: 427.46
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: IRAK