(E/Z)-Necrosulfonamide, CAS 432531-71-0

Product Description: (E/Z)-Necrosulfonamide is a racemic compound of Necrosulfonamide (HY-100573). Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome complex from interacting with its downstream effectors. MLKL is a critical substrate of RIP3 during the induction of necrosis[1][2].

Formula: C18H15N5O6S2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Sun L, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227.

CAS Number: 432531-71-0

Molecular Weight: 461.47

Compound Purity: 98.84

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Mixed Lineage Kinase

• SKU: MEXHY-100573A-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-100573A-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK