Product Description: E/Z-SIS3 free base exhibits an inhibitory efficacy against smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3 signaling pathway[1].
Applications: COVID-19-immunoregulation
Formula: C28H27N3O3
References: [1]Shou J, et al., SIS3, a specific inhibitor of smad3, attenuates bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 2018 Sep 5;503(2):757-762.
CAS Number: 1009104-85-1
Molecular Weight: 453.53
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: TGF-beta/Smad