EBET-1055

Product Description: EBET-1055 is a bromodomain and extra-terminal (BET) protein degrader (EBET) composed of a BET inhibitor (EBET-590, HY-161387), an E3 ubiquitin ligase ligand and connectors. EBET-1055 effectively inhibits the growth of pancreatic ductal adenocarcinoma (PDAC). EBET-1055 also simultaneously modulates cancer-associated fibroblast (CAF) activity, upregulating all reporter gene activities in organoid co-cultures[1].

Applications: Cancer-Kinase/protease

Formula: C51H54N8O9

References: [1]Nakazawa Y, et al. Delivery of a BET protein degrader via a CEACAM6-targeted antibody-drug conjugate inhibits tumour growth in pancreatic cancer models. Nat Commun. 2024 Mar 11;15(1):2192.

Molecular Weight: 923.02

Research Area: cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Epigenetic Reader Domain

• SKU: MEXHY-161346-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161346-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK