EM12-SO2F, CAS 2803819-61-4

Product Description: EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells[1][2]

Applications: Cancer-programmed cell death

Formula: C13H11FN2O5S

References: [1]Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023./[2]Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3(9):1105-1110.

CAS Number: 2803819-61-4

Molecular Weight: 326.30

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Others

• SKU: MEXHY-W760183-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-W760183-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK