Product Description: Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
Applications: Neuroscience-Neurodegeneration
Formula: C16H18Cl2N2OS
Citations: Eur J Pharmacol. 2017 Sep 15;811:110-116./Faculty of Health Sciences. 2020 Oct./Neuron. 2017 May 17;94(4):840-854.e7. /Journal of High School Science. 2023 Oct 5./Psychopharmacology (Berl). 2019 Apr;236(4):1245-1253.
References: [1]Prickaerts J, et al. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2012 Feb;62(2):109/[2]Thomas Papouin, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94:1-15./[3]Papouin T, et al. Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness. Neuron. 2017 May 17;94(4):840-854.e7./[4]Maehara S, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 2A inhibitor, PDM-631. Eur J Pharmacol. 2017 Sep 15;811:110-116.
CAS Number: 550999-74-1
Molecular Weight: 357.30
Compound Purity: 98.77
Research Area: Neurological Disease
Solubility: DMSO : ≥ 50 mg/mL
Target: nAChR
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