Entrectinib, CAS 1108743-60-7

Description: Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M resistance mutations, and inhibits ALK‐dependent signaling. It has been shown to inhibit the growth of a non-small cell lung Y cell line bearing an EML4-ALK rearrangement. In mice bearing various ROS1, Trk, or ALK-driven xenografts, Entrectinib has been shown to induce tumor regression.

CAS Number: 1108743-60-7

Formula: C31H34F2N6O2

Molecular Weight: 560,64

References: Rolfo C, et al. Expert Opin Investig Drugs. 2015, 24(11), 1493-1500.

• SKU: TGMT3678-1mL
• Manufacturer: TargetMol Chemicals
• Manufacturer SKU: T3678-1mL
• Package Unit: 1 mL
• Quantity Unit: STK