ERK1/2 inhibitor 10

Product Description: ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1/2 inhibitor (IC50: 0.11/0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations[1].

Formula: C23H20ClN5O2S

References: [1]Shuai W, et al. Structure-Guided Discovery and Preclinical Assessment of Novel (Thiophen-3-yl)aminopyrimidine Derivatives as Potent ERK1/2 Inhibitors. J Med Chem. 2024 Apr 25;67(8):6425-6455.

Molecular Weight: 465.96

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ERK

• SKU: MEXHY-162460-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-162460-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK