Product Description: EZH2-IN-17 (compound 28) is a potent and orally active EZH2 inhibitor with an IC50 value of 0.95 nM. EZH2-IN-17 exhibits high anti-proliferation activity against different lymphoma cell lines including WSU-DLCL2, Pfeiffer and Karpas-422 (IC50 values of 2.36 nM, 1.73 nM, and 1.82 nM, respectively)[1].
Applications: Cancer-programmed cell death
Formula: C36H46N4O4
References: [1]Xin Xu, et al. Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2). Bioorg Med Chem Lett. 2023 Nov 11:129558.
CAS Number: 2489672-09-3
Molecular Weight: 598.77
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Histone Methyltransferase