FzM1.8, CAS 2204290-85-5

Product Description: FzM1.8 derives from FzM1, is an allosteric agonist of FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K[1].

Applications: Cancer-programmed cell death

Formula: C18H14N2O4

References: [1]Riccio G, et al. A Negative Allosteric Modulator of WNT Receptor Frizzled 4 Switches into an Allosteric Agonist. Biochemistry. 2018 Feb 6;57(5):839-851.

CAS Number: 2204290-85-5

Molecular Weight: 322.31

Compound Purity: 98.37

Research Area: Cancer

Solubility: DMSO : 83.33 mg/mL (ultrasonic)

Target: Wnt;β-catenin

• SKU: MEXHY-117163-100
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-117163-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK