GLPG1837, CAS 1654725-02-6

Product Description: GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

Formula: C16H20N4O3S

References: [1]Van der Plas SE, et al. Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61(4):1425-1435./[2]Yeh HI, et al. A common mechanism for CFTR potentiators. J Gen Physiol. 2017 Dec 4;149(12):1105-1118.

CAS Number: 1654725-02-6

Molecular Weight: 348.42

Compound Purity: 99.86

Research Area: Others

Solubility: DMSO : ≥ 250 mg/mL

Target: Autophagy;CFTR

• SKU: MEXHY-111099-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-111099-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK