Glucocorticoid receptor/NF-κB modulator-1

Product Description: Glucocorticoid receptor/NF-κB modulator-1 (Compound 20) is a derivative of ocotillol. Glucocorticoid receptor/NF-κB modulator-1 suppresses the degradation of glucocorticoid receptor (GR) mRNA and GR protein, inhibits the activation of NF-κB signaling pathway. Glucocorticoid receptor/NF-κB modulator-1 downregulates levels of NO, interleukin-6 and tumor necrosis factor-alpha (TNF-α). Glucocorticoid receptor/NF-κB modulator-1 ameliorates sepsis in mouse model[1].

Formula: C39H62N2O6S

References: [1]Ma G, et al., Discovery of novel ocotillol derivatives modulating glucocorticoid receptor/NF-κB signaling for the treatment of sepsis. Eur J Med Chem. 2024 May 5;271:116427.

Molecular Weight: 686.98

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Glucocorticoid Receptor;NF-κB

• SKU: MEXHY-161520-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161520-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK